研究業績

2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1987

2020

334) Sato K, Ihara R, Suzuki K, Niimi Y, Toda T, Jimenez-Maggiora G, Langford O, Donohue MC, Raman R, Aisen PS, Sperling RA, Iwata A, Iwatsubo T: Predicting amyloid risk by machine learning algorithms based on the A4 screen data: application to the Japanese Trial-Ready Cohort study. Alzheimers Dementia: Translational Research & Clinical Interventions in press
333) Matsukawa K, Kukharsky, Park S-K, Park S, Iwatsubo T, Hashimoto T, Liebman S, Shelkovnikova T: Long non-coding RNA NEAT1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy. RNA Biol in press
332) Levine SZ, Yoshida K, Goldberg Y, Samara M, Cipriani A, Efthimiou O, Iwatsubo T, Leucht S, Furukawa TA: Linking the Mini-Mental State Examination, the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Severe Impairment Battery: Evidence from five randomized clinical trials. Evid Based Ment Health in press
331) Hashimoto T, Fujii D, Naka Y, Kashiwagi-Hakozaki M, Matsuo Y, Matsuura Y, Wakabayashi T, Iwatsubo T: Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques. Acta Neuropathol Comm 8:212, 2020
330) Kuwahara T, Funakawa K, Komori T, Sakurai M, Yoshii G, Eguchi T, Iwatsubo T: Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation. Neurobiol Dis 145:105081, 2020
329) Sato K, Mano T, Suzuki K, Toda T, Iwatsubo T, Iwata A: Attempt to predict A/T/N-based Alzheimer's disease cerebrospinal fluid biomarkers using a peripheral blood DNA methylation clock. J Alzheimers Dis Rep 4:287-296, 2020
328) Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata J-i, Niikura T, Yasui M: Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Acta Neuropathol Comm 8: 67, 2020
327) Suzuki K, Hirakawa A, Ihara R, Iwata A, Ishii K, Ikeuchi T, Sun C-K, Donohue M, Iwatsubo T: Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer’s disease. Alzheimers Dementia: Translational Research & Clinical Interventions 6:e12007, 2020
326) Okada Y, Kato T, Iwata K, Kimura Y, Nakamura A, Hattori H, Toyama H, Ishii K, Ishii K, Senda M, Ito K, Iwatsubo T: Evaluation of PiB visual interpretation with CSF Aβ and longitudinal SUVR in J-ADNI study. Ann Nucl Med 34: 108-118, 2020

2019

325) Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T：Roles of collagen XXV and its putative receptors PTPσ/δ in intramuscular motor innervation and congenital cranial dysinnervation disorder. Cell Rep 29: 4362-4376, 2019
324) Tanaka Y, Yamada K, Satake K, Nishida I, Heuberger M, Kuwahara T, Iwatsubo T: Seeding activity-based detection uncovers the different release mechanisms of seed-competent tau versus inert tau via lysosomal exocytosis. Front Neurosci 13:1258, 2019
323) Sato K, Mano T, Matsuda H, Senda M, Ihara R, Suzuki K, Arai H, Ishii K, Ito K, Ikeuchi T, Kuwano R, Toda T, Iwatsubo T, Iwata A: Visualizing modules of coordinated structural brain atrophy during the course of Alzheimer's disease conversion by applying methodology from gene co-expression analysis. Neuroimage Clinical 24:101957, 2019
322) Park S, Park S-K, Watanabe N, Hashimoto T, Iwatsubo T, Shelkovnikova TA, Liebman SW: Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies. PLOS Genetics 15:e1008308, 2019
321) Yagi T, Kanekiyo M, Ito J, Ihara R, Suzuki K, Iwata A, Iwatsubo T, Aoshima K: Identification of prognostic factors to predict cognitive decline of early Alzheimer’s disease patients in the Japanese Alzheimer’s Disease Neuroimaging Initiative study. Alzheimers Dementia: Translational Research & Clinical Interventions 5:364-373, 2019
320) Eto M, Hashimoto T, Shimizu T, Iwatsubo T: Characterization of the unique in vitro effects of unsaturated fatty acids on the formation of amyloid beta fibrils. PLOS One 14:e0219465, 2019
319) Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T: Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease. Mol Neurodegener 14:15, 2019
318) Goncalves TJM, Boutillon F, Lefebvre S, Goffin V, Chanoine C, Iwatsubo T, Wakabayashi T, Oury F, Armand AS: Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation. Sci Rep 9:5878, 2019
317) Sato K, Mano T, Ihara R, Suzuki K, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Iwatsubo T, Toda T, Iwata A: Lower serum calcium as a potential risk factor for mild cognitive impairment conversion to early Alzheimer’s disease in Japanese Alzheimer’s Disease Neuroimaging Initiative. J Alz Dis 68:777-788, 2019
316) Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A: Chronic cerebral hypoperfusion shifts the equilibrium of amyloid beta oligomers to aggregation-prone species with higher molecular weight. Sci Rep 9:2827, 2019
315) Ishida T, Tokuda K, Hisaka A, Honma M, Iwatsubo T, Moritoyo T, Suzuki H, Alzheimer’s Disease Neuroimaging Initiative. Development of a novel method to estimate chronological changes in disease progression. Clin Pharmacol Therapeut 105: 436-447, 2019

2018

314) Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T: Clinical and cognitive characteristics of preclinical Alzheimer’s disease in the Japanese ADNI cohort. Alzheimers Dementia: Translational Research& Clinical Interventions 4:645-651, 2018
313) Iwata A, Iwatsubo T, Ihara R, Suzuki K, Matsuyama Y, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H: Effects of gender, educational background, and renal function on cognitive and functional decline in Japanese patients with mild cognitive impairment. Alzheimers Dementia: Translational Research & Clinical Interventions 4:765-774, 2018
312) Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci USA 115:E9115-E9124, 2018
311) Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerriere A, Prasher V, Iwatsubo T, Strydom A: Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease. Acta Neuropathol 136:569-587, 2018
310) Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC: Japanese and North American Alzheimer’s Disease Neuroimaging Initiative studies: harmonization for international trials. Alzheimers Dementia 14:1077-1087, 2018
309) Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T: Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Hum Mol Genet 27: 1353-1365, 2018
308) Yamada K, Iwatsubo T: Activity-dependent pathway determines extracellular alpha-synuclein levels. Molecular Neurodegeneration 13:9, 2018
307) Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T: Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology. Biochem Biophys Res Commun 495:1708-1715, 2018
306) Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T: Loss of kallikrein-related peptidase 7 derived from astrocytes exacerbates amyloid pathology in Alzheimer disease model mouse. EMBO Mol Med pii: e8184, 2018

2017

305) Mano T, Tsuchida T, Ohtomo R, Nagata K, Takahashi-Fujigasaki J, Murayama S, Saido TC, Yamashita S, Ushijima T, Hashimoto T, Tamaoka A, Ikeuchi T, Iwatsubo T, Tsuji S, Iwata A: Epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease. Proc Natl Acad Sci USA 114:E9645-E9654, 2017
304) Yamamoto T, Furihata K, Hisaka A, Moritoyo T, Furihata S, Ogoe K, Kusayama S, Motohashi K, Mori A, Iwatsubo T, Suzuki H: Notable drug-drug interaction between etizolam and itraconazole in poor metabolizers of cytochrome P450 2C19. J Clin Pharmacol 57:1491-1499, 2017
303) Fujishima M, Kawaguchi A, Maikusa N, Kuwano R, Iwatsubo T, Matsuda H, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI): Sample size estimation for Alzheimer’s disease trials from Japanese ADNI serial MRI. J Alzheimers Dis 56:75-88, 2017

2016

302) Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T: ALS-linked mutations in profilin 1 exacerbate degeneration in the retina of Drosophila melanogaster through increasing the cytoplasmic localization of TDP-43. J Biol Chem 291:23464-23476, 2016
301) Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T: BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Hum Mol Genet 25:2948-2958, 2016
300) Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T: Partial loss of CALM function reduces A42 production and amyloid deposition in vivo. Hum Mol Genet pii: ddw239, 2016
299) Ikari Y, Akamatsu G, Nishio T, Ishii K, Ito K, Iwatsubo T, Senda M: Phantom criteria for qualification of brain FDG and amyloid PET across different cameras EJNMMI Physics 3:23, 2016
298) Kuwahara T, Inoue K, D'Agati VD, Fujimoto T, Eguchi T, Saha S, Wolozin B, Iwatsubo T, Abeliovich A: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. Sci Rep 6:29945, 2016
297) Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T: A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Sci Rep 6:23969, 2016
296) Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T: Conformational changes in transmembrane domain 4 of presenilin 1 are associated with altered Abeta42 production. J Neurosci 36:1362-1372, 2016
295) Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DMA, Iwatsubo T, Hasegawa M: Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol 131:267-280, 2016

2015

294) Doody RS, Raman, R Sperling RA, Siemers E, Sethuraman G, Mohs R, Farlow MR, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS; Alzheimer’s Disease Cooperative Study: Peripheral and central effects of gamma-secretase inhibition by semagacestat in Alzheimer's disease. Alzheimer's Research & Therapy 7:36, 2015
293) Yamamoto K, Tanei Z I, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno L E, Fukayama M, Bito H, Cirrito J R, Holtzman D M, Deisseroth K, Iwatsubo T: Chronic Optogenetic Activation Augments Abeta Pathology in a Mouse Model of Alzheimer Disease. Cell Rep 11:859-865, 2015
292) Hori Y, Hashimoto T, Nomoto H, Hyman B T, Iwatsubo T: Role of apolipoprotein E in beta-amyloidogenesis: isoform-specific effects on protofibril to fibril conversion of Abeta in vitro and brain Abeta deposition in vivo. J Biol Chem, 2015
291) Kukharsky M S, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman V L, Shelkovnikova T A: Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Mol Neurodegener 10:20, 2015
290) Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T: Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of gamma-secretase. J Neurosci 35:2646-2656, 2015
289) Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T: Synthetic ceramide analogues increase amyloid-beta 42 production by modulating gamma-secretase activity. Biochem Biophys Res Commun 457:194-199, 2015
288) Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K: Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study. Radiol Phys Technol 8:64-72, 2015
287) Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H: Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Hum Mol Genet 24:540-558, 2015

2014

286) Villemagne V L, Kim S Y, Rowe C C, Iwatsubo T: Imago Mundi, Imago AD, Imago ADNI. Alzheimers Res Ther 6:62, 2014
285) Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev I K, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, Fukuyama T, Tomita T, Iwatsubo T: Allosteric regulation of gamma-secretase activity by a phenylimidazole-type gamma-secretase modulator. Proc Natl Acad Sci U S A 111:10544-10549, 2014
284) Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T: New photocleavable linker: alpha-thioacetophenone-type linker. Bioorg Med Chem Lett 24:2831-2833, 2014
283) Ito G, Fujimoto T, Kamikawaji S, Kuwahara T, Iwatsubo T: Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955. PLoS One 9:e97988, 2014
282) Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T: Decreased CALM expression reduces Abeta42 to total Abeta ratio through clathrin-mediated endocytosis of gamma-secretase. Nat Commun 5:3386, 2014
281) Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T: CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci 34:1370-1379, 2014
280) Doody R S, Thomas R G, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen P S, Siemers E, Liu-Seifert H, Mohs R: Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med 370:311-321, 2014
279) Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T: Binding of longer Abeta to transmembrane domain 1 of presenilin 1 impacts on Abeta42 generation. Mol Neurodegener 9:7, 2014
278) Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M: Attenuation of the aggregation and neurotoxicity of amyloid-beta peptides by catalytic photooxygenation. Angew Chem Int Ed Engl 53:1382-1385, 2014
277) Li Y, Lu S H, Tsai C J, Bohm C, Qamar S, Dodd R B, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman B T, Tomita T, Iwatsubo T, Johnson C M, Farrer L A, Schmitt-Ulms G, Fraser P E, St George-Hyslop P H: Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure 22:125-135, 2014

2013

276) Imabayashi E, Matsuda H, Tabira T, Arima K, Araki N, Ishii K, Yamashita F, Iwatsubo T: Comparison between brain CT and MRI for voxel-based morphometry of Alzheimer's disease. Brain Behav 3:487-493, 2013
275) Kamikawaji S, Ito G, Sano T, Iwatsubo T: Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation. Biochemistry 52:6052-6062, 2013
274) Doody R S, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas R G, Aisen P S, Siemers E, Sethuraman G, Mohs R: A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med 369:341-350, 2013
273) Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T: Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. BMC Biochem 14:16, 2013
272) Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T: RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Hum Mol Genet 22:4474-4484, 2013
271) Maikusa N, Yamashita F, Tanaka K, Abe O, Kawaguchi A, Kabasawa H, Chiba S, Kasahara A, Kobayashi N, Yuasa T, Sato N, Matsuda H, Iwatsubo T: Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom. Med Phys 40:062303, 2013
270) Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T: FTY720/fingolimod, a sphingosine analogue, reduces amyloid-beta production in neurons. PLoS One 8:e64050, 2013
269) Goto M, Abe O, Aoki S, Hayashi N, Miyati T, Takao H, Iwatsubo T, Yamashita F, Matsuda H, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K: Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects. Neuroradiology 55:869-875, 2013
268) Tomita T, Iwatsubo T: Structural biology of presenilins and signal peptide peptidases. J Biol Chem 288:14673-14680, 2013
267) Takahashi R, Ishii K, Senda M, Ito K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T: Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study. Ann Nucl Med 27:452-459, 2013
266) Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T: Effect of helical conformation and side chain structure on gamma-secretase inhibition by beta-peptide foldamers: insight into substrate recognition. J Med Chem 56:1443-1454, 2013
265) Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T: Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry 52:61-69, 2013

2012

264) Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zheng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T: Activity-dependent proteolytic cleavage of neuroligin-1. Neuron 76:410-422, 2012
263) Takeo K, Watanabe N, Tomita T, Iwatsubo T: Contribution of γ-secretase cofactors to the formation of catalytic pore of presenilin 1. J Biol Chem 287:25834-25843, 2012
262) Goto M, Abe O, Miyati T, Kabasawa H, Takao H, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Mori H, Kunimatsu A, Aoki S, Ino K, Iida K, Yano K, Ohtomo K, Japanese Alzheimer’s Disease Neuroimaging Initiative: Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method. Korean Journal of Radiology 13:391-402, 2012
261) Goto M, Abe O, Kabasawa H, Takao H, Miyati T, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Inano S, Mori H, Kunimatsu A, Aoki S, Ino K, Yano K, Ohtomo K, Japanese Alzheimer’s Disease Neuroimaging Initiative: Effects of Image Distortion Correction on Voxel-based Morphometry. Magneteic Resonance in Medical Sciences 11:27-34, 2012
260) Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider B, Lee M: Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci 32:3306-3320, 2012
259) Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T: Phosphorylation at Ser129 reduces α-synuclein neurotoxicity by lowering its membrane-binding property in Caenorhabditis elegans. J Biol Chem 287:7098-7109, 2012
258) Hayashi I, Takatori S, Urano Y, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T: Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene 31:787-798, 2012
257) Ito G, Iwatsubo T: Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form. Biochem J 441:987-994, 2012

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2011

256) Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S: Comparison of preselinin1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. J Biol Chem 286:44569-44575, 2011
255) Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H: Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. PLoS One 6:e27408, 2011
254) Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T: Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J 30:4815-4824, 2011
253) Miyashita H, Maruyama Y, Isshiki H, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T: Three-dimensional structure of the signal peptide peptidase. J Biol Chem 286: 26188-26197, 2011
252) Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S-i, Kamiie J, Hashimoto T, Hosoya K-i, Iwatsubo T, Terasaki T: Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. J Neurochem 118:407-415, 2011
251) Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH: Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7:280-292, 2011
250) Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T: BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. J Neurosci 31: 6850-6857, 2011

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2010

249) Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T: Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. J Neurosci 30: 15943-15950, 2010
248) Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K: Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer’s disease. J Neurosci Res 88:3588-3597, 2010
247) Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M: Seeded aggregation and toxicity of α-synuclein and tau: cellular models of neurodegenerative diseases. J Biol Chem 285:34885-34898, 2010
246) Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H: Novel Notch-sparing γ-secretase inhibitors derived from a peroxisome proliferator- activated receptor agonist library. Bioorg Med Chem Lett 20:5282-5285, 2010
245) Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M: A non-competitive BACE1 inhibitor TAK-070 ameliorates Aβ pathology and behavioral deficits in a mouse model of Alzheimer’s disease. J Neurosci 30:11157-11166, 2010
244) Watanabe N, Takagi S, Tomita T, Iwatsubo T: Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate binding site of γ-secretase. J Biol Chem 285:19738-19746, 2010
243) Cheung KH, Mei L, Mak DOD, Hayashi I, Iwatsubo T, Kang DE, Foskett JK: Gain of function Alzheimer’s disease presenilin regulation of InsP3 receptor modal gating in patient cells and AD mouse neurons. Science Signaling 3:ra22, 2010

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2009

242) Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S: Dual antitumor mechanisms of Notch signaling inhibitor in a T cell acute lymphoblastic leukemia xenograft model. Cancer Sci 100:2444-2450, 2009
241) Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T: Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorg Med Chem Lett 19:6869-6871, 2009
240) Kamikawaji S, Ito G, Iwatsubo T: Identification of the autophosphorylation sites of LRRK2. Biochemistry 48:10963-10975, 2009
239) Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrieze F, Dartigues JF, Tzourio C, Buee L, Pasquier F, Berr C, Mann D, Lendon C, Alperovitch A, Kamboh MI, Amouyel P, Lambert JC: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease. Mol Psychiatr 14:1004-1016, 2009
238) Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T: Single chain variable fragment against Nicastrin inhibits the γ-secretase activity. J Biol Chem 284:27838-27847, 2009
237) Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T: Aβ immunotherapy: intracerebral sequestration of Aβ by an anti-Aβ monoclonal antibody 266 with high affinity to soluble Aβ. J Neurosci 29: 11393-11398, 2009
236) Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B: LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci 29:9210-9218, 2009
235) Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H: Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol Pharm Bull 32:999-1003, 2009
234) Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T: Inhibition of γ-secretase activity by helical β-peptide foldamers. J Am Chem Soc 131:7353-7359, 2009
233) Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P: Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson’s disease. Human Molecular Genetics 18: 872-887, 2009
232) Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G: s-Palmitoylation of γ-secretase subunits nicastrin and Aph-1. J Biol Chem 284:1373-1384, 2009

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2008

231) Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhan J: Lysosomal enzyme cathepsin D protects against α-synuclein aggregation and toxicity. Molecular Brain 1:17, 2008
230) Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T: The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem 283: 34554-34562, 2008
229) Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe, M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S: Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 67:945-953, 2008
228) Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren C-H, Kato T, Mitani S, Iwatsubo T: A large-scale RNA interference screen identifies endocytic pathway genes as modifiers of α-synuclein toxicity in transgenic Caenorhabditis elegans. Human Molecular Genetics 17:2997-3009, 2008
227) Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH: Evaluation of α-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 116:277-288, 2008
226) Lo Bianco C, James Shorter C, Regulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P: Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson’s disease. J Clin Invest 118:3087-3097, 2008
225) Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL: Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors. J Enzyme Inhib Med Chem 7:1, 2008
224) Cheung K-H, Shineman D, Muller M, Cardenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM-Y, Foskett K: Mechanism of Ca2+ disruption in Alzheimer’s disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58:871-883, 2008
223) Sato C, Takagi S, Tomita T, Iwatsubo T: The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the γ-secretase. J Neurosci 28: 6264-6271, 2008
222) Ichibangase T, Saimaru H, Takamura N, Kuwahara T, Koyama A, Iwatsubo T, Imai K: Proteomics of Caenorhabditis elegans overexpressing human α-synuclein analyzed by FD-LC-MS/MS method: actin and several ribosomal proteins were identified as negative markers at early Parkinson’s disease stages. Biomedical Chromatography 22:232-234, 2008
221) Obi, K Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H: Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 210:409-420, 2008
220) Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K: Immunoreactivity of phage library-derived human single-chain antibodies to amyloid β conformers in vitro. J Biochem 143:475-486, 2008
219) Akanuma SI, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T: ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier. Neurochem Int 52:956-961, 2008
218) Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG: Leucine-rich repeat kinase 2 colocalizes with α-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neurodegener Dis 5: 222-224, 2008
217) Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan C-F, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A: Homozygous and heterozygous patients for SNCA duplication in family with parkinsonism and dementia. Arch Neurol 65:514-519, 2008
216) Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S-i, Kobayashi K, Iwatsubo T, Yoshimoto M: Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice. Neurobiol Aging 29:574-585, 2008
215) Kumano K, Masuda S, Sata M, Saito T, Lee S-Y, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocytehomeostasis. Pigment Cell & Melanoma Research 21:70-78, 2008
214) Takatori S. Ito G, Iwatsubo T: Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. Neurosci Lett 430:13-17, 2008

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2007

213) Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T: Enhanced accumulation of phosphorylated α-synuclein and elevated Aβ42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer disease. J Neurosci 27:13092-13, 2007
212) Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi R, Hisanaga S-i, Iwatsubo T, Hasegawa M, Kato K: 920 MHz ultra-high field NMR studies of antibody binding and site-specific phosphorylation of α-synuclein. Biochem Biophys Res Comm 363:795-799, 2007
211) Ishii A, Nonaka T, Taniguchi S, Saito T, Arai, T, Mann D, Iwatsubo T, Hisanaga S-i, Goedert M, Hasegawa M: Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human α-synuclein: Implication for α-synucleinopathies. FEBS letters 581:4711-4717, 2007
210) Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T: Analytical method for β-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of β-amyloid protein aggregation. Anal Chem 79:4887-4891, 2007
209) Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T: Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic γ-secretase inhibitors. ACS Chemical Biology 2:408-418, 2007
208) Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T: Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Org Lett 9:2055-2058, 2007
207) Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kosaka K, Kato M, Iwatsubo T, Arai H: Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies. Neurosci Lett 415:219-224, 2007
206) Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M: Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein. J Neurosci Res 85:1819-1825, 2007
205) Haleem K, Lippa CF, Wong M, Abdelhak T, Smith TW, Kowa H, Iwatsubo T: Space-occupying plaques in PS-1 C410Y Alzheimer’s disease contain synaptic- terminal specific proteins. American Journal of Alzheimer’s Disease 22:137-144, 2007
204) Fumimura Y, Ikemura M, Saito Y, Sengoku R, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Mizusawa H, Murayama S: Analysis of adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol 66: 354-362, 2007
203) Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T: Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 amino-terminal elongation and fenofibrate. J Biol Chem 282:12388-12396, 2007
202) Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK, for the DLB/PDD working Group: DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and Biomarkers. Neurology 68:812-819, 2007
201) Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T: The Tottori (D7N) and English (H6R) familial Alzheimer's disease mutations accelerate Aβ fibril formation without increasing protofibril formation. J Biol Chem 282: 4916-4923, 2007
200) Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T: GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson’s disease. Biochemistry 46:1380-1388, 2007

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2006

199) Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M: Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates. Heterocycles 70:101-106, 2006
198) Zhu X, Babar A, Siedlak LS, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG. LRRK2 in Parkinson's disease and dementia with Lewy bodies. Molecular Neurodegeneration 1:17, 2006
197) Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R: AMPA-R removal underlies Aβ-induced synaptic depression. Neuron 52:831-843, 2006
196) Sato C, Morohashi Y, Tomita T, Iwatsubo T: Structure of the catalytic pore of γ-secretase inferred by the accessibility of substituted cysteines. J Neurosci 26: 12081-12088, 2006
195) Ozaki , Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A: The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochem Biophys Res Comm 351:57-63, 2006
194) Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min DS, Kim J, Paik SR, Chung KC: Dyrk1A phosphorylates α-synuclein and enhances intracellular inclusion formation. J Biol Chem 281: 33250-33257, 2006
193) Arawaka S, Wada M, Goto S, Karube H, Sakamoto M, Ren C-H, Koyama S, Nagasawa H, Kimura H, Kawanami T, Kurita K, Tajima K, Daimon M, Baba M, Kido T, Saino S, Goto K, Asao H, Kitanaka C, Takashita E, Hongo S, Nakamura T, Kayama T, Suzuki Y, Kobayashi K, Katagiri T, Kurokawa K, Kurimura M, Toyoshima I, Tsuchiya K, Iwatsubo T, Muramatsu M, Matsumine H, Kato T: The role of G protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson’s disease. J Neurosci 26:9227-9238, 2006
192) Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H: Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters 16:4184-4189, 2006
191) Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kato M, Iwatsubo T, Kosaka K, Arai H: Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies. J Neurol Sci 246:95-101, 2006
190) Tomita T, Tanaka S, Morohashi Y, Iwatsubo T: Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration 1:2 (doi:10.1186/1750-1326-1-2), 2006
189) Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zola P, Arima K, Iseki E, Murayama S, Kretzchmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Khan N, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Mann DMA: Comparison of extent of tau pathology in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer’s disease. Neuropathol Appl Neurobiol 32:374-387, 2006
188) Bensemain F, Chapuis J, Tian J, Shi J, Thaker U, Lendon C, Iwatsubo T, Amouyel P, Mann D, Lambert J-C: Association study of the ubiquilin gene with Alzheimer's disease. Neurobiol Dis 22:691-693, 2006
187) Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T: Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver. Pharmaceut Res 23: 1407- 1416, 2006
186) Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quelever G, Iwatsubo T, Kraus J-L: Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, enzymatic BACE-1 and cell assays. J Med Chem 49:4275-4285, 2006
185) Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T: Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters 16:3813-3816, 2006
184) Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T: Carboxyl-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT. J Biol Chem 281: 14670-14676, 2006
183) Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga S-i, Goedert M, Hasegawa M: Small molecule inhibitors of α-synuclein filament assembly. Biochemistry 45:6085-6094, 2006
182) Tian J, Shi J, Smallman R, Iwatsubo T, Mann DMA Relationships in Alzheimer’s disease between the extent of Aβ deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen. Neuropathol Appl Neurobiol 32: 332-340, 2006
181) de Silva R, Lashley T, Strand C, Shiarli A-M, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Revesz T, Mann DMA: An immunohisto- chemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol 111: 329-340, 2006
180) Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C: Three-dimensional structure of the γ-secretase complex. Biochem Biophys Res Comm 343: 525-534, 2006
179) Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DMA: Genetic associations between cathepsin D exon 2 CRT polymorphism and Alzheimer’s disease, and pathological correlations with genotype. J Neurol Neurosurg Psychiatry 77: 515-517, 2006
178) Shi J, Tian J, Pritchard A, Lendon C, Lambert J-C, Iwatsubo T, Mann DMA: A 3’-UTR polymorphism in the oxidized LDL receptor 1 gene increases Aβ40 load as cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol 111:15-20, 2006
177) Ito G, Ariga H, Nakagawa Y, Iwatsubo T: Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. Biochem Biophys Res Comm 339:667-672, 2006
176) Kuwahara T, Koyama A, Gengyo-Ando K, Masuda M, Kowa H, Tsunoda M, Mitani S, Iwatsubo T: Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic C. elegans. J Biol Chem 281:334-340, 2006

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2005

175) McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM-Y, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, for the Consortium on DLB: Dementia with Lewy Bodies: Diagnosis and Management: Third Report of the DLB Consortium. Neurology 65:1863-1872, 2005
174) Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel D, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K: Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J 19:2069-2071, 2005
173) Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T: Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 1. J Biol Chem 280:41967-41975, 2005
172) Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E: Neurological and neurodegenerative alterations in a transgenic mouse model expressing α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci 25:10689-10699, 2005
171) Lambert JC, Mann D, Richard F, Tian J, Shi J, Thaker U, Merrot S, Harris J, Frigard B, Iwatsubo T, Lendon C, Amouyel P: Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease? J Neurol Neurosurg Psychiatry 76:928-933, 2005
170) Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA: α-Synuclein phosphorylation enhances Lewy body-like inclusion formation in SH-SY5Y cells. J Neurosci 25:5544-5552, 2005
169) Pritchard A, Harris J, Pritchard CW, St Clair D, Lemmon H, Lambert JC, Chartier-Harlin MC, Hayes A, Thaker U, Iwatsubo T, Mann DM, Lendon C: Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer's disease. Neurosci Lett 382:221-226, 2005
168) Machida Y, Chiba T, Takayanagi A, Tanaka Y, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Tanaka K, Mizuno Y, Hattori N: Common anti-apoptotic roles of parkin and α-synuclein in human dopaminergic cells. Biochem Biophys Res Commun 332:233-240, 2005
167) Iseki E, Marui W, Yamamoto R, Togo T, Katsuse O, Kato M, Iwatsubo T, Kosaka K, Arai H: The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neurosci Lett 380:161-165, 2005
166) Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T: Association of active γ-secretase complex with lipid rafts. J Lipid Res 46:904-912, 2005
165) Niimura M, Isoo N, Takasugi N, Tsuruoka M, Tei-Ui K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T: Aph-1 contributes to the stabilization and trafficking of the γ-secretase complex through mechanisms involving inter- and intramolecular interactions. J Biol Chem 280: 12967-12975, 2005
164) Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T: CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280: 8596-8605, 2005
163) Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M: Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins. J Biol Chem 280: 7614-7623, 2005
162) Nonaka T, Iwatsubo T, Hasegawa M: Ubiquitination of α-synuclein. Biochemistry 44:361-368, 2005

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2004

161) Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P: Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson’s disease. Proc Natl Acad Sci USA 101:17510-17515, 2004
160) Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H: Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9. Resemblance to pathogenetic changes in Parkinson’s disease. J Neurochem 91:451-461, 2004
159) Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T: Selective reconstitution and recovery of functional γ-secretase complex on budded baculovirus particles. J Biol Chem 279: 38040-38046, 2004
158) Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M: Phosphorylated α-synuclein in normal mouse brain. FEBS lett 572: 227-232, 2004
157) Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M and Saya H: Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation. J Cell Biol 165:893-902, 2004
156) Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DMA, Duff K, Tsuji S, Hashimoto T, Iwatsubo T: Mostly separate distributions of CLAC- versus Aβ40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of β-amyloid deposits. Am J Pathol 165: 273-281, 2004
155) Zhang Y, Hayes A, Pritchard A, Haque MS, Lemmon H, Harris J, Cumming A, Lambert JC, Chartier-Harlin MC, St Clair D, Iwatsubo T, Mann DM, Lendon CL: Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer’s disease. Neurosci Lett 362:99-102, 2004
154) Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K: Novel amyloid precursor protein missense mutation (D678N) in familial Alzheimer’s disease. J Neurol Neurosurg Psychiatr 75: 1039-1042, 2004
153) Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K: Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice. Eur J Neurosci 19:2826-2838, 2004
152) Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, Al-Saraj S, Killick R, Pickering-Brown S, Moore P, Hollingworth P, Archer N, Foy C, Walter S, Lendon C, Iwatsubo T, Morris JC, Norton J, Mann D, Janssens B, Hardy J, O’Donovan M, Jones L, Williams J, Holmans P, Owen MJ, Grupe A, Powell J, van Hengel J, Goate A, Van Roy F, Lovestone S: α-T-catenin is expressed in human brain and interacts with the Wnt signalling pathway but is not responsible for linkage to chromosome 10 in Alzheimer’s disease. Neuromolecular Medicine 5:133-146, 2004
151) Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity. Bioorg Med Chem Lett 14:1983-1985, 2004
150) Umeda Y, Taniguchi S, Arima K, Piao Y-SH, Takahashi H, Iwatsubo T, Mann D, Hasegawa M: Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neurosci Lett 359:151-154, 2004
149) Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: Accumulation of phosphorylated α-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 107:292-298, 2004
148) Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H: Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues. Tetrahedron Letters 45: 2323-396, 2004
147) Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian M: Aggresomes formed by α-synuclein and synphilin-1 are cytoprotective. J Biol Chem 279:4625-4631, 2004
146) Lambert JC, Mann D, Harris J, Araria-Goumidi L, Chartier-Harlin MC, Cottel D, Iwatsubo T, Amouyel P, Lendon C: Association study of Notch 4 polymorphisms with Alzheimer's disease. J Neurol Neurosurg Psychiatry 75:377-381, 2004
145) Matsubayashi H, Sese S, Lee J-S, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S-i. Biochemical characterization of Drosophila Wingless signaling pathway based on RNA interference. Mol Cell Biol 24:2012-2024, 2004
144) Taniguchi S, McDonagh AM, Pickering-Brown SA, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA: The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathol Appl Neurol 30: 1-18, 2004

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2003

143) Soderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM-Y, Trojanowski JQ, Naslund J: Molecular identification of AMY, and Alzheimer disease amyloid-associated protein. J Neuropathol Exp Neurol 62: 1108-1117, 2003
142) Schroeter EH, Ilagan MXG, Brunkan AL, Hecimovic S, Li Y-M, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Shearman M, Goate A, Wolfe MS, Kopan R: A presenilin dimer at the core of the γ-secretase enzyme? Insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci USA 100: 13075-13080, 2003
141) Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chem Commun 17:2244-2245, 2003
140) Lambert JC, Luedecking-Zimmer E, Merrot S, Hayes A, Thaker U, Desai P, Houzet A, Hermant X, Cottel D, Pritchard A, Iwatsubo T, Pasquier F, Frigard B, Conneally PM, Chartier-Harlin MC, DeKosky ST, Lendon C, Mann D, Kamboh MI, Amouyel P: Association of 3 '-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. J Medical Genetics 40: 424-430, 2003
139) Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I: Analysis of neurons created from wild-type and Alzheimer’s mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. J Neurosci 23:8513-8525, 2003
138) Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: α-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy. J Neuropathol Exp Neurol 62: 812-819, 2003
137) Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated α-synuclein in aging human brain. J Neuropathol Exp Neurol 62:644-654, 2003
136) Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T: Sulindac sulfide is a non-competitive γ-secretase inhibitor that preferentially reduces Aβ42 generation. J Biol Chem 278: 18664-18670, 2003
135) Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R: APP processing and synaptic function. Neuron 37: 925-937, 2003
134) Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 422:438-441, 2003
133) Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H: Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 22: 1511-1516, 2003
132) Thaker U, McDonagh AM, Iwatsubo T, Lendon CL, Pickering-Brown SM, Mann DMA: Tau load is associated with apolipoprotein E genotype and the amount of amyloid β protein Aβ40 in sporadic and familial Alzheimer’s disease. Neuropathol Appl Neurobiol 29:35-44, 2003
131) Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic Drosophila. Neurosci Lett 336:155-158, 2003

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2002

130) Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T: The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J Biol Chem 277: 50198-50205, 2002
129) Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann DMA, Iwatsubo T: Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002
128) Leem JY, Saura CA, Pietrzik C, Kim S-H, Veselits ML, Christianson J, Wanamaker C, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo E-H, Thinakaran G: A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 11:64-82, 2002
127) Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice and in Lewy body disease patients. J Clin Invest 110: 1429-1439, 2002
126) Matsushita S, Arai H Okamura N, Ohmori T, Takasugi, Matsui T, Murayama M, Iwatsubo T, Higuchi S: Clinical and biomarker investigation of a patient with a novel PS-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer’s disease. Biological Psychiatry 52:907-910, 2002
125) Hayes A, Thakera U, Iwatsubo T, Pickering-Brown SM, Mann DMA: Pathological relationships between microglial cell activity and tau and amyloid β protein in patients with Alzheimer’s disease. Neurosci lett 331: 171-174, 2002
124) Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak T W, Penninger J M, Nishina H, Katada T: SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kB-induced anti-apoptosis. Dev Biol 250: 332-347, 2002
123) Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Haass C, Takeda M: Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1. EMBO J 21:5408-5416, 2002
122) Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T: A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neurosci Lett 330:84-88, 2002
121) Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin MC, Iwatsubo T, Pickering-Brown SM, Mann DMA: The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease. Neurosci Lett 328:314-318, 2002
120) Araria-Goumidi L, Lambert JC, Mann DMA, Lendon C, Frigard B, Iwatsubo T, Cottel D, Amouyel P, Chartier-Harlin MC: Association study of three polymorphisms of TGF-β1 gene with Alzheimer’s disease. J Neurol Neurosurg Psychiatr 73:62-64, 2002
119) Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun 294:429-440, 2002
118) Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C: Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Report 3: 583-588, 2002
117) Green EK, Harris JM, Lemmon H, Lambert JC, Chartier-Harlin MC, St Clair D, Mann DMA, Iwatsubo T, Lendon CL. Are interleukin-1 gene polymorphisms risk factors or disease modifiers in Alzheimer’s disease. Neurology 58:1566-1568, 2002
116) Tomita T, Katayama R, Takikawa R, Iwatsubo T: Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. FEBS lett 520:117-121, 2002
115) Green EK, Thaker U, McDonagh AM, Iwatsubo T, Lambert JC, Chartier-Harlin MC, Harris JM, Pickering-Brown SM, Lendon CL, Mann DMA: A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain. Neurosci Lett 324:113-116, 2002
114) Miake H, Mizusawa H, Iwatsubo T*, Hasegawa M*: Biochemical characterization of the core structure of α-synuclein filaments. J Biol Chem 277: 19213-19219, 2002 (*corresponding author)
113) Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T: Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem 277: 14965-14975, 2002
112) Lambert J-C, Thaker U, Green EK, Harris JM, McDonagh AM, Iwatsubo T, Chartier-Harlin MC, Pickering-Brown SM, Lendon CL, Mann DMA: The -48 C/T polymorphism within the promotor region of the presenilin-1 gene does not influence the extent of tau pathology within the brain in sporadic Alzheimer’s disease. Alzheimer’s Reports 5:13-16, 2002
111) Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51:525-530, 2002
110) Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DMA, Iwatsubo T: CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J 21:1524-1534, 2002
109) Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T: α-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biol 4:160-164, 2002

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108) Ikegaya Y, Kim J-A, Baba M, Iwatsubo T, Nishiyama N, Matsuki N: Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: Implication for a cellular defense against excitotoxicity. J Cell Sci 114:4083-4093, 2001
107) Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C: Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 159:2215-2225, 2001
106) Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T: The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation and γ-secretase activities of presenilins. J Biol Chem 276:33273-33281, 2001
105) Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 309:89-92, 2001
104) Mann DMA, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M, Kalimo H, Iwatsubo T: Cases of Alzheimer’s disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic β amyloid pathology known as “cotton wool” plaques. Neuropathol Applied Neurobiol 27:189-196, 2001
103) Lambert J-C, Mann D, Harris J M, Chartier-Harlin M-C, Cummings A, Coates J, Lemmon H, St-Clair D, Iwatsubo T, Lendon C: The -48 CT polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Aβ load in brain. J Medical Genetics 38:353-355, 2001
102) Iwata H, Tomita T, Maruyama K, Iwatsubo T: Subcellular compartment and molecular subdomain of β-amyloid precursor protein relevant to the Aβ42-promoting effects of Alzheimer mutant presenilin 2. J Biol Chem 276: 21678-21685, 2001
101) Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC: Neprilysin degrades both amyloid β peptide 1-40 and 1-42 most effectively among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 276: 21895-21901, 2001
100) Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T: Amyloid angiopathy and variability in Amyloid β deposition is determined by mutation position in presenilin-1 linked Alzheimer’s disease. Am J Pathol 158: 2165-2175, 2001
99) Verkkoniemi A, Kalimo H, Paetau A, Somer M, Iwatsubo T, Hardy J, Haltia M: Variant Alzheimer’s disease with spastic paraparesis: Neuropathological phenotype. J Neuropathol Exp Neurol 60: 483-492, 2001
98) Mann DMA, McDonagh AM, Pickering-Brown SM, Kowa H, Iwatsubo T: Amyloid β protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype. Neurosci Lett 304:161-164, 2001
97) Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol 49:501-511, 2001
96) Piao Y-S, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi T: Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 101:285-293, 2001
95) Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y: Molecular cloning and expression of the novel splice variants of K+ channel-interacting protein 2 (KChIP2). Biochem Biophys Res Comm 282:96-102, 2001
94) Lambert J-C, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon CL, Chartier-Harlin M-C: Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease. Lancet 357:608-609, 2001
93) Lee J-A, Long, Z, Nimura N, Iwatsubo T, Imai K, Homma H: Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands. Arch Biochem Biophys 385:242-249, 2001
92) Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. FEBS letters 489: 46-50, 2001

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2000

91) Pickering-Brown S, Baker M, Yen S-H, Liu W-K, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, Hutton M: Pick’s disease is associated with mutations in the tau gene. Ann Neurol 48:859-867, 2000
90) Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim S-H, Thinakaran G, Sisodia SS, Snyder SH: Amyloid precursor proteins inhibit heme oxygenase activity and augument neurotoxicity in Alzheimer’s disease. Neuron 28: 461-473, 2000
89) Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B, Cottel D, Lendon C, Iwatsubo T, Amouyel P, Chartier-Harlin : A FE65 polymorphism associated with risk of developing sporadic late-onset Alzheimer's disease but not with Aβ loading in brains. Neurosci Lett 293:29-32, 2000
88) Wakabayashi K, Shibasaki Y, Hasegawa M, Horikawa Y, Soma Y, Hayashi S, Morita T, Iwatsubo T, Takahashi H: Primary progressive aphasia with focal glial tauopathy. Neuropathol Appl Neurobiol 26:477-481, 2000
87) Yamazaki M, Arai Y, Baba M, Iwatsubo T, Mori O, Katayama Y, Oyanagi K: α-synuclein inclusions in amygdala in the brains of patients with Parkinsonism-Dementia Complex of Guam. J Neuropathol Exp Neurol 59: 585-591, 2000
86) Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DMA, Hyman BT, Iwatsubo T: Age-related amyloid β deposition in transgenic mice overexpressing both presenilin 1 and amyloid β precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 157: 331-339, 2000
85) Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA, Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in the brains of patients with Down’s syndrome. Alzheimer Report 3:77-82, 2000
84) Saura CA, Tomita T, Soriano S, Takahashi M, Leem J-Y, Honda T, Koo EH, Iwatsubo T, Thinakaran G: The non-conserved hydrophilic loop domain of presenilin is neither required for presenilin endoproteolysis nor enhanced Aβ42 production mediated by FAD-linked PS variants. J Biol Chem 275:17136-17142, 2000
83) Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal dementia and parkinsonism with an N279K mutation of tau gene. Neurology 54:1787-1795, 2000
82) Yasuda M, Takamatsu J, D’Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Iwatsubo T, Goedert M, Schellenberg G, Tanaka C: A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 47:422-429, 2000
81) Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T: Molecular cloning and characterization of a novel CLIC-related protein, parchorin, expressed in water-secreting cells. J Biol Chem 275:11164-11173, 2000
80) Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-calpain. Int J Mol Med 5:269-273, 2000
79) Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi H: Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disese) with diffuse neurofibrillary and Lewy body pathology. Acta Neuropathol 99:331-336, 2000
78) Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle P, Haass C: Constitutive phosphorylation of the Parkinson’s disease associated α-synuclein. J Biol Chem 275:390-397, 2000

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1999

77) Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T: C terminus of presenilin is required for overproduction of amyloidogenic Aβ42 through stabilization and endoproteolysis of presenilin. J Neurosci 19:10627-10634, 1999
76) Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H: Cerebrospinal fluid levels of amyloid β-peptide1-42, but not tau have positive correlation with brain glucose metabolism. Neurosci Lett 273:203-207, 1999
75) Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T: Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid b peptides ending at Aβ40 and Aβ42. Neuroreport 10:2965-2969, 1999
74) Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C: A loss of function mutation of presenilin-2 interferes with amyloid β peptide production and Notch signaling. J Biol Chem 274:28669-28673, 1999
73) Wang G-H, Mitsui K, Kotliarova S, Yamashita A, Nagao Y, Tokuhiro S, Iwatsubo T, Kanazawa I, Nukina N: Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells. Neuroreport 12:2435-2438, 1999
72) McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon, SE, Wang R, Hsiao K, Mann D, Dickson D, Duff K: Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis 6:231-244, 1999
71) Lee J-A, Homma H, Tashiro K, Iwatsubo T, Imai K: D-Asprtate localization in the rat pituitary gland and retina. Brain Res 838:193-199, 1999
70) Jakes R, Crowther RA, Lee VM-Y, Trojanowski JQ, Iwatsubo T, Goedert M: Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein. Neurosci Lett 269:13-16, 1999
69) Nishiyama K, Ikezu T, Trapp BD, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Dekosky ST, Hsiao KK, Lisanti MP, Okamoto T: Caveolin-3 up-regulation activates γ-secretase mediated cleavage of the amyloid precursor protein (APP) in Alzheimer’s disease. J Neurosci 19: 6538-6548, 1999
68) Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A: Enhancement of amyloid β 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease. Neurosci Lett 265: 61-63, 1999
67) Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G: Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. J Biol Chem 274: 13818-13823, 1999
66) Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, la Pompa JL, Furlonger K, Paige C, Hui Cc, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, Penninger JM: Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126:505-516, 1999

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1998

65) Iseki E, Marui W, Kosaka K, Akiyama H, Ueda K, Iwatsubo T: Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease. Neurosci Lett 258:81-84, 1998
64) Hosomi A, Goto K, Kondo H, Iwatsubo T, Yokota T, Ogawa M, Arita M, Aoki J, Arai H, Inoue K: Localization of alpha-tocopherol transfer protein in rat brain. Neurosci Lett 256:159-162 1998
63) Naruse S, Thinakaran G, Luo J-J, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty, DD, Price, DL, Borchelt DR, Wong PC, Sisodia SS: Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 17:1213-1221, 1998
62) Hosoda R, Saido TC, Otvos LJr, Arai T, Mann DMA, Lee VM-Y, Trojanowski JQ, Iwatsubo T: Quantification of modified forms of amyloid β peptides in Alzheimer’s disease and Down’s syndrome brains. J Neuropathol Exp Neurol 57: 1089-1095, 1998
61) Lippa CF, Fujiwara H, Mann DMA, Giasson B, Baba M, Schmidt ML, Nee LE, O’Connell B, Pollen DA, St Geroge-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM-Y, Iwatsubo T, Trojanowski JQ: Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer’s disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 153:1365-70, 1998
60) Sakai K, Homma H, Lee JA, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Imai K: Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system. Brain Res 808: 65-71, 1998
59) Long Z, Homma H, Lee JA, Fukushima T, Santa T, Iwatsubo T, Yamada R, Imai K: Biosynthesis of D-aspartate in mammalian cells. FEBS Lett 434:231-235, 1998
58) Tu P-H, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM-Y: Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 44: 415-422, 1998
57) Mann DMA, Pickering-Brown SM, Baba M, Iwatsubo T: Amyloid β protein (Aβ) deposition in dementia with Lewy bodies: predominance of Aβ42(43) and paucity of Aβ40 compared with sporadic Alzheimer’s disease. Neuropathol Applied Neurobiol 24: 187-194, 1998
56) Takigawa Y, Homma H, Lee J-A, Fukushima T, Santa T, Iwatsubo T, Imai K: D-aspartate uptake into cultured rat pinealocytes and the concomitant effect on L-aspartate levels and melatonin secretion. Biochem Biophys Res Comm 248: 641-647, 1998
55) Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayashi T, Ishiguro K, Harigaya Y, Wakabayashi K, Okamoto K, Hirai S, Shoji M: Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40 and Aβ1-42(43) in Alzheimer’s disease: A study in Japan. Ann Neurol 44: 17-26, 1998
54) Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T: Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid β peptides: Inability of truncated forms of PS2 with familial Alzheimer’s disease mutation to increase secretion of Aβ42. J Biol Chem 273: 21153-21160, 1998
53) Shinozaki K, Maruyama K, Saido TC, Kume H, Tomita T, Iwatsubo T, Obata K: The presenilin 2 loop domain interacts with the μ-calpain C-terminal region. Int J of Mol Med 1: 797-799, 1998
52) Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grunberg J, Ueyama Y, Haass C, Ihara Y: Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid β-protein (Aβ)42 in the brain. J Neurochem 71:313-322, 1998
51) Baba M, Nakajo S, Tu P-H, Tomita T, Nakaya K, Lee VM-Y, Trojanowski JQ, Iwatsubo T: Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies. Am J Pathol 152: 879-884, 1998
50) Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T: The presenilin 1 mutation (M146V) linked to familial Alzheimer’s disease attenuates the neuronal differentiation of NTera 2 cells. Biochem Biophys Res Comm 244: 751-755, 1998
49) Sakai K, Homma H, Lee J-A, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Imai K: Localization of D-aspartic acid in elongate spermatids in rat testis. Arch Biochem Biophys 351: 96-105, 1998
48) Tomita T, Chang TY, Kodama T, Iwatsubo T: βAPP γ-secretase and SREBP site 2 protease are two different enzymes. Neuroreport 5: 911-913, 1998
47) Schmidt ML, Lee VM-Y, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ: Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of Aβ similar to those found in the amyloid plaques of Alzheimer’s disease and pathological aging. Acta Neuropathol 95:117-122, 1998

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1997

46) Sakurai Y, Matsumura K, Iwatsubo T, Momose T: Frontal pure agraphia for Kanji and Kana: dissociation between morphology and phonology. Neurology 49:946-952, 1997
45) Galvin JE, Lee VM-Y, Baba M, Mann DMA, Dickson DW, Yamaguchi H, Schmidt ML, Iwatsubo T, Trojanowski JQ: Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit. Ann Neurol 42:595-603, 1997
44) Cook DG, Forman M, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM-Y, Doms RW: Alzheimer Aβ (1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nature Med 3:1021-1023, 1997
43) Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T: Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport 8:2797-2801, 1997
42) Sakai K, Homma H, Lee J-A, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Imai K: D-aspartic acid localization during postnatal development of rat adrenal gland. Biochem Biophys Res Comm 235:433-436, 1997
41) Takamatsu J, Kimura T, Kondo A, Iwatsubo T: Subpial amyloid plaques in the cerebellum in a case of Alzheimer's disease. Dement Geriatr Cogn Disord 8:157-162, 1997
40) Kosaka T, Imagawa M, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A, Fukushima T, Imai K, Iwatsubo T: The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid β protein ending at Aβ42(43). Neurology 48:741-745, 1997
39) Lee J-A, Homma H, Sakai K, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Yoshikawa M, Imai K: Immunohistochemical localization of D-aspartate in the rat pineal gland. Biochem Biophys Res Comm 231:505-508, 1997
38) Mann DMA, Pickering-Brown SM, Byatti NN, Wright AE, Owen F, Iwatsubo T, Saido TC: An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid β protein deposition in Alzheimer's disease. Neurosci Lett 222:57-60, 1997
37) Mann DMA, Iwatsubo T, Pickering-Brown SM, Owen F, Saido TC, Perry RH: Preferential deposition of amyloid β protein (Aβ) in the form of Aβ40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neurosci Lett 221:81-84, 1997
36) Tomita T, Maruyama K*, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Gruenberg J, Haass C, Iwatsubo T*, Obata K: The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 94:2025-2030, 1997 (*corresponding author)
35) Mann DMA, Iwatsubo T, Nochlin D, Sumi M, Levy-Lahad E, Bird TD: Amyloid (Aβ) deposition in chromosome 1-linked Alzheimer's disease. --The Volga German families. Ann Neurol 41:52-57, 1997

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1996

34) Iwatsubo T, Saido TC, Mann DMA, Lee VM-Y, Trojanowski JQ: Full-length amyloid-β (1-42(43)) as well as amino-terminally modified and truncated amyloid-β42(43) deposit in diffuse plaques. Am J Pathol 149:1823-1830, 1996
33) Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K: Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of Aβ42(43). Biochem Biophys Res Comm 227:730-735, 1996
32) Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S: Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain. Neurosci Lett 215:173-176, 1996
31) Kanemaru K, Iwatsubo T, Ihara Y: Comparable amyloid β protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain. Neurosci Lett 214:196-198, 1996
30) Mann DMA, Iwatsubo T, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD, Poorkaj P, Hardy J, Hutton M, Prihar G, Crook R, Rossor MN, Haltia M: Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: predominance of Aβ42(43). Ann Neurol 40:149-156, 1996
29) Mann DMA, Iwatsubo T: Diffuse plaques in the cerebellum and corpus striatum in Down's syndrome contain amyloid β protein (Aβ) only in the form of Aβ42. Neurodegeneration 5:115-120, 1996
28) Mann DMA, Iwatsubo T, Snowden JS: Atypical amyloid (Aβ) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific Aβ monoclonal antibodies. Acta Neuropathol 91:647-653, 1996
27) Yamatsuji T, Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H, Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, Kinane B, Giambarella U, Nishimoto I: G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science 272:1349-1352, 1996
26) Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM-Y: Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am J Pathol 148:1517-1529, 1996
25) Mann DMA, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman MLC, Rossor MN: Predominant deposition of amyloid β42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral haemorrhage associated with mutations in the APP gene. Am J Pathol 148:1257-1266, 1996
24) Kume H, Maruyama K, Tomita T, Iwatsubo T, Saido TC, Obata K: Molecular cloning of a novel basic helix-loop-helix protein from rat brain. Biochem Biophys Res Comm 219:526-530, 1996
23) Nakano I, Iwatsubo T, Otsuka N, Kamei M, Matsumura K, Mannen T: Some unusual astrocytic responses against ghost tangles in a long survival case of juvenile Alzheimer's disease--An electron microscopic study-- J Neurol Sci 136:41-46, 1996
22) Fukumoto H, Asami-Odaka A, Suzuki N, Iwatsubo T: Association of Aβ40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals. Neurodegeneration 5:13-17, 1996
21) Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T: Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: predominance of Aβ42(43) and association of Aβ40 with cored plaques. Am J Pathol 148:259-266, 1996

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1995

20) Mann DMA, Iwatsubo T, Ihara Y, Fukumoto H, Odaka A, Suzuki N: Microglial cells and amyloid β protein (Aβ) deposition; association with Aβ40 containing plaques. Acta Neuropathol 90:472-477, 1995
19) Mann DMA, Pickering-Brown S, Siddons MA, Iwatsubo T, Ihara Y, Odaka A, Suzuki N: The extent of amyloid deposition in brain in Down's syndrome does not depend upon the apolipoprotein E genotype. Neurosci Lett 196:105-108, 1995
18) Iwatsubo T, Mann DMA, Odaka A, Suzuki N, Ihara Y: Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome. Ann Neurol 37:294-299, 1995
17) Saido TC, Iwatsubo T, Mann DMA, Ihara Y, Shimada H, Kawashima S: Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques. Neuron 14:457-466, 1995

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1994

16) Arai H, Higuchi S, Muramatsu T, Iwatsubo T, Sasaki H, Trojanowski JQ: Apolipoprotein E gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease. Lancet 344:1307, 1994
15) Iwatsubo T, Hasegawa M, Ihara Y: Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathol 88:129-136, 1994
14) Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y: High tissue content of soluble β 1-40 is linked to cerebral amyloid angiopathy. Am J Pathol 145:452-460, 1994
13) Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y: Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ-monoclonals: Evidence that an initially deposited species is Aβ42(43). Neuron 13:45-53, 1994

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1993

12) Nakano I, Iwatsubo T, Hashizume Y, Mizutani T: Bunina bodies in neurons of the medullary reticular formation in amyotrophic lateral sclerosis. Acta Neuropathol 85:471-474, 1993
11) Endo R, Ogawara M, Iwatsubo T, Nakano I, Mori H: Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease. Brain Res 601:164-172, 1993

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1992

10) Sonoo M, Genba K, Iwatsubo T, Mannen T: P15 in tibial nerve SEPs as an example of the junctional potential. Electroencephal Clin Neurophysiol 84: 486-491, 1992
9) Bito H, Nakamura M, Honda Z, Izumi T, Iwatsubo T, Seyama Y, Ogura A, Kudo Y, Shimizu T: Platelet-activating factor (PAF) receptor in the rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Neuron 9:285-294, 1992
8) Nakano I, Iwatsubo T, Hashizume Y, Mizutani T, Mannen T: Amyotrophic lateral sclerosis with dementia-- Lesions in the apical cortex and some deeper structures of the temporal lobe. Neuropathology 12: 69-77, 1992
7) Takahashi N, Iwatsubo T, Nakano I, Machinami R: Focal appearance of cerebellar torpedoes associated with discrete lesions in the cerebellar white matter. Acta Neuropathol 84:153-156, 1992
6) Wakabayashi T, Oka S, Shimada K, Nakano I, Iwatsubo T, Mori S: Disseminated pneumocystis carinii infection in a hemophilic patient with acquired immunodeficiency syndrome. Acta Pathol Japonica 42: 262-266, 1992
5) Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y: Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. Am J Pathol 140:277-282, 1992
4) Nakano I, Iwatsubo T, Otsuka N, Kamei M, Matsumura K, Mannen T: Paired helical filaments in astrocytes: Electronmicroscopy and immunohistochemistry in a case of atypical Alzheimer's disease. Acta Neuropathol 83:228-232, 1992

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1991

3) Iwatsubo T, Nakano I, Fukunaga K, Miyamoto E: Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies. Acta Neuropathol 82:159-163, 1991

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1990

2) Iwatsubo T, Kuzuhara S, Kanemitsu A, Shimada H, Toyokura Y: Corticofugal projections to the motor nuclei of the brainstem and spinal cord in humans. Neurology 40:309-312, 1990

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1987

1) Iwatsubo T, Iwata M, Inoue K, Mannen T: Imagerie par resonance magnetique dans un cas de l'infarctus mesencephalique paramedian. Rev Neurol 143:605-607, 1987

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